Zhang Yuanying set up a car overturn, even the nationality is fake, why is the hypoglycemic drug still in charge of losing weight?

Did Zhang Yuanying have Mercury retrograde recently…

When I attended an event in Paris two days ago, because I failed to show off my English level, I was questioned by netizens that someone with a high degree of education overturned the car.

When he turned his head and was picked up again, not only people pretended to be false, but even his nationality might be false.

I won’t go into details about the complexity of this melon, but in a nutshell:

Zhang Yuanying’s grandfather came to Korea from Shandong in 1930 and has not yet acquired Korean nationality. Moreover, their whole family only married Chinese or Chinese.

Isn’t this fun!

I think when Zhang Yuanying made his debut in the talent show variety show, South Korean manpower lined up a lot of foreign players, and South Korea’s Zhang Yuanying was promoted to C position in the finals.

It can be said that he is the national C position who keeps Korea’s self-esteem. As a result, the bamboo basket is empty, and it is actually a Chinese person…

But it may be dizzy. The body that has been praised by Korean net for breaking through genes has now become a slot.

It was said that she was morbidly thin and lost weight too much, causing her body to overturn, and she also released the previous stage pictures.

Although, some fans came forward to accuse the exposed pictures of being P’s, and marked the modification marks on the arms, waist and thighs.

But netizens don’t buy it, after all, the gap between before and after the P picture is really not big.

It seems that the hat of excessive weight loss cannot be taken off.

But let’s u1s1, we really can’t blame the stars themselves in this situation, who makes the entertainment industry really too convoluted.

Especially in South Korea, many entertainment companies even expressly stipulate that artists are not allowed to work as long as they gain weight.

But as the general public, we have neither the requirement to be photographed nor the red line of weight, but there are still people who will do anything to lose weight, and even po to show a crooked atmosphere.

For example, the news that adults saw today: hypoglycemic drugs have been transformed into magic drugs for weight loss .

However, because semaglutide is a prescription drug, although many doctors do not prescribe it to “patients”, they will resell it privately at high prices.

As a result, the use of medicines has increased sharply, and the prices have become more and more expensive, and even affected the normal demand for medicines.

Why are hypoglycemic drugs still in charge of losing weight?

Semaglutide, which is in the limelight , was not originally used for weight loss.

Instead , it is a hypoglycemic drug for diabetics – GLP-1 receptor agonists .

The hormone GLP-1 (glucagon-like peptide-1) is actually a physiological hormone secreted by L cells in the terminal jejunum, ileum, and colon under feeding and neuroendocrine stimulation .

GLP-1 can not only enhance β-cell response and stimulate insulin secretion ; it can also reduce glucagon secretion by acting on α-cells, thereby reducing hepatic glucose output and reducing blood sugar .

It is worth mentioning that, in addition to the several functions mentioned above, semaglutide is also an important function – weight loss .

In other words, its popularity is not groundless, but well-founded.

It mainly reduces body weight through central and peripheral mechanisms.

Because the hypoglycemic mechanism of semaglutide involves delaying gastric emptying and gastrointestinal motility .

This process will make people feel full, inhibit the feeding center, and at the same time increase energy consumption , thereby achieving the effect of weight loss.

It is precisely because of this additional function of weight loss that semaglutide has become popular in the Chinese market.

As for the fire to what extent?

It went on sale in China in April last year and was included in medical insurance in December. As a result, it only took half a year to reach $46 million in sales in China.

Since July this year, hospitals and pharmacies in many areas have been out of stock.

The price has also been raised from less than 500 yuan to 1000+.

Is indiscriminate weight loss reliable?

Sisters who lose weight may have heard a saying: losing weight is difficult, and losing weight with a small base is even more difficult.

But the adults found that this problem does not exist in the face of semaglutide, and all are treated equally.

No matter how big or small your weight base is, as long as you use this medicine, you can knock off the scale.

This kind of indiscriminate weight loss makes adults feel that it has nothing to do with fat or thin.

I even believe that even a single injection of the human skeleton in the laboratory can lose five pounds.

Although last June, the US FDA approved semaglutide for chronic weight management in obese or overweight adults .

However, the regulations can only be used for:

1. Body mass index (BMI) ≥ 27kg/m2 and at least one weight-related disease, such as hypertension, type 2 diabetes or high cholesterol;

2. Patients with BMI≥30kg/m2.

In my country, the currently approved indications for semaglutide are only adults with type 2 diabetes and vascular disease.

As for the treatment of simple overweight and obese patients, it has not been approved at all .

Therefore, the treatment of obesity with semaglutide lacks the support of data from domestic clinical trials .

In addition to the lack of clinical data to support, blindly pursuing weight loss and ignoring its side effects is also a big problem.

It can be seen that the most common side effects after semaglutide administration are: hypoglycemia, nausea, vomiting, diarrhea , etc.

Phase IIIa clinical trial data showed that people with low body weight were more likely to experience gastrointestinal reactions when used.

In severe cases, acute pancreatitis may also occur , accompanied by severe abdominal pain, bloating, nausea, and vomiting .

If you don’t care about these, you think that as long as you can lose weight, you can endure no matter how uncomfortable it is.

The adult will tell you another sad fact. Studies have shown that after people who use semaglutide to lose weight stop the drug, 2/3 of the people have regained weight .

Chang Rongshan, a Chinese virologist, said: GLP-1, as a gut-derived hormone, is closely related to blood sugar concentration and needs to be stimulated by carbohydrates to be released into the blood.

Therefore, even if there is a weight loss effect after use, it will rebound immediately once it is stopped.

Long-term use can also greatly increase the risk of medullary thyroid cancer and pancreatitis .

Translated into the vernacular, it means: take medicine indiscriminately when you are not sick, be careful of serious illness!

Moreover, the FDA has also banned the use of two groups of people:

One is patients with medullary thyroid cancer personal history and family history; the other is patients with multiple endocrine neoplasia type 2.

Can other “magic medicines” be used?

Of course, there are more than just these strange slimming pills on the Internet. The pits that everyone steps on are also punished one by one.

# Sibutramine

If there is a small partner who is an OG in the weight loss circle, then the name sibutramine is definitely no stranger.

It was once regarded as a slimming drug because it can make people lose weight easily. It was only later that it became a banned drug and was forcibly removed from the shelves.

Sibutramine is actually a central nervous system depressant that was first used to treat depression.

But later in clinical application, it was found that its weight loss effect was significantly better than that of antidepressant.

Sibutramine suppresses appetite mainly by blocking neuromediator reuptake, while increasing glucose utilization and thermogenesis in adipose tissue, increasing energy expenditure, and thereby reducing body weight .

Sibutramine was approved by the FDA for weight loss in 1997, and was subsequently approved for marketing in the United States, the European Union, Japan and other countries and regions.

In 2000, sibutramine was also approved as a prescription drug in my country.

At that time, the most popular non-Tai Chi Group’s “Qumei Diet Pill” was probably the most popular in China. Adults have also seen its advertisements when they were young.

However, shortly after sibutramine was marketed as a weight loss drug, reports of adverse reactions and serious side effects began to appear.

Such as insomnia, vomiting, constipation, and serious cardiovascular risks .

Including non-fatal myocardial infarction, non-fatal stroke, resuscitable cardiac arrest, cardiovascular mortality, etc.

Share a SCOUT research result with you:

This is a six-year, randomized, double-blind, multicenter trial conducted in Europe, Latin America, and Australia from January 2003 to March 2009.

It was found that sibutramine .

So since 2010, the US FDA has taken action, recommending against the use of sibutramine.

In 2010, China also banned the production of diet pills containing sibutramine, and listed sibutramine as a prohibited drug .

Although the state has banned the sale of sibutramine, there are still some netizens who are buying at high prices, and there are still criminals who take risks.

For example, the Internet celebrity Gu Zaozao showed off his wealth last year because he committed a crime against the wind and illegally sold diet pills containing sibutramine.

# Orlistat

Of course, not all the so-called magic drugs are illegal.

There is also this weight loss drug that has been on TV commercials. It is also the only weight loss drug approved for marketing in China so far – orlistat .

Orlistat can inhibit gastrointestinal lipase, which simply inhibits the decomposition and absorption of body fat .

Mainly by inhibiting the absorption of triglycerides in the intestinal tract to expel oil, thereby reducing calorie intake and achieving the purpose of weight loss.

Although it is an FDA-approved drug for obesity treatment. But the drug is poisonous, and orlistat is not immune.

First of all, because of its unique mechanism of action, it will affect the absorption of fat-soluble vitamins and beta carotene, thereby causing malnutrition .

Therefore, during the medication, we must remember to supplement the multivitamins containing fat-soluble vitamins (vitamins A, D, E, K) .

Second, it can seriously affect the quality of life!

Such as uncontrollable oil discharge , and the more oily the diet, the more oil is discharged.

It may even uncontrollably defecate (oil) , even with a peculiar smell, which is very easy to cause social death.

It is best to prepare in advance. Adults recommend wearing lala pants, otherwise you will wait to wash your underwear .

A small number of people also have gastrointestinal adverse reactions, which may cause liver damage .

Therefore, even if orlistat is a weight loss drug approved by the state, adults do not recommend that you use it at will, and you must follow the doctor’s advice.

It was found that no, these so-called slimming magic drugs, whether or not they have been approved by the state, all have one common feature – obvious side effects .

Maybe these drugs that help you suppress your appetite and lose weight will have some effects, but all of this is just passing by, and once you stop the drugs, you will be beaten back to the original state.

I hope that the sisters will maintain health, lose weight rationally, follow the doctor’s advice, and avoid detours while respecting science .

But when it comes to health, I wonder if the sisters have noticed. As more and more girls begin to pay attention to gynecological health, more businesses have begun to launch a lot of women’s health self- services under the slogan of “early inspection and early detection”. Check the product .

For example, hpv self-test box, gynecological disease self-test card…

However, it is understandable that some girls do have a sense of fear about going to the hospital and a sense of shame about gynecological diseases.

For these sisters, using self-test products is indeed a more comfortable option.

In addition, considering the registration and time issues, it is impossible for us to go to the hospital every time we feel unwell.

This health self-assessment product is simply gospel!

But…convenience is convenience, what makes adults puzzled is.

Is this self-test product reliable? Can we rely on readily available self-test products for health testing?