Inhaled new crown vaccine starts vaccination, what is the possibility of “one shot against cancer”? |A week of health must read

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The “fourth shot” of the new crown vaccine is here? Shanghai launches inhalation vaccination

On October 26, Shanghai launched the inhalation of the recombinant new coronavirus vaccine (adenovirus type 5 vector) for the use of citizens who have not completed the booster immunization.

The so-called booster vaccination generally refers to the third vaccination after the first two routine vaccinations. The second booster immunization shot proposed today is regarded as the “fourth shot”.

This inhaled new crown vaccine is produced by CanSino Biological Co., Ltd. Before that, it was only used in individual emergency scenarios. The inhaled new crown vaccine is identical in composition to the previously injected vaccine, but the injection method has changed.

Zhu Tao, the chief scientific officer of CanSino, said in an interview with the media that the inhaled adenovirus vector vaccine only uses 1/5 of the dose, which is much safer than the existing intramuscular injection vaccine, and the level of neutralizing antibody is higher than that of intramuscular injection. To strengthen the inactivated vaccine, the neutralizing antibody can be increased by more than 10 times.

Virology expert Chang Rongshan believes that the side effects of inhaled vaccines are relatively low. Vaccines may be less prone to symptoms such as fever and fatigue, plus less pain from a single injection. Therefore, inhaled vaccines are more friendly than injectable vaccines, which may increase their appeal.

In addition, some experts believe that the effect of the inhaled new crown vaccine can only be conservatively optimistic. Due to insufficient clinical data, it may be feasible as a fast-acting emergency short-acting solution, but the long-term effect needs further observation.

(Source: CanSino Bio)

Unexplained kidney disease in Indonesia may be linked to dangerous chemicals in syrups taken by patients

On October 24, Indonesian Health Minister Budi Gunadi Sadikin informed that the number of children with unexplained kidney disease in the country had increased to 245 cases, of which 38 were cured and discharged, and 141 died.

According to Sadikin, based on surveys of the patients’ medications and references from the World Health Organization, the cause may be that the syrups the patients were taking contained dangerous chemicals. Previously, the Indonesian Food and Drug Administration conducted a sampling test of syrup drugs in the country, and the results showed that there were five syrup drugs with excessive levels of diethylene glycol and ethylene glycol.

“The number of new patients admitted to hospital for acute kidney disease has dropped significantly,” Sadikin said after asking all health institutions and pharmacies in Indonesia to temporarily stop prescribing liquid or syrup medicines.

The “Chinese Heart” with full magnetic levitation brings “heart cancer” patients back to life

As the first batch of domestically produced fully magnetic levitation artificial heart implanters in my country, Wang Shiqi, who suffered from “heart cancer” – dilated cardiomyopathy, appeared on the stage of “Talk Show” and told the audience about his artificial heart implantation experience to the national audience.

“A pipe as thick as a washing machine drain pipe needs to be connected to the stomach and all the way to the heart, and the battery that powers the artificial heart is so large that it needs a cart to push it.” The previous generation of artificial hearts once asked Wang Shiqihe His mother shied away. What brought new life to Wang Shiqi was my country’s domestically produced fully magnetic levitation artificial heart, which had already started clinical trials before Wang Shiqi’s transplant. Compared with the previous generation of artificial hearts, it was smaller and more portable and had better performance.

Academician Hu Shengshou, a leading figure in the field of cardiovascular disease in China, introduced at the 2022 China Heart Disease Conference that since the first “Chinese Heart” implantation in China in 2017, 33 hospitals in China have carried out a total of more than 200 cases of left ventricle. Assistive device implantation surgery.

Wang Shiqi (Source: Tencent Video)

Can a single mRNA vaccine treat cancer? “The Lancet” sub-journal publishes a heavy review

Recently, THE LANCET Oncology, an international authoritative journal in the field of oncology, published a major review, detailing the past and present of mRNA cancer vaccines, showing new prospects for mRNA vaccines in cancer treatment.

The main purpose of cancer vaccination is to induce or enhance an effective anti-tumor immune response. At present, mRNA vaccines are mainly administered by intravenous administration, subcutaneous injection, intranasal administration, intralymphatic administration, intramuscular injection, intratumoral injection and intradermal injection. deliver.

The vast majority of mRNA cancer vaccines currently under clinical investigation are therapeutic vaccines rather than prophylactic vaccines. The review highlights that therapeutic mRNA cancer vaccines are more likely to be successful in combination with other immunotherapy strategies, such as immune checkpoint inhibitors, oncolytic viruses, and adoptive cell therapy. Single-agent mRNA cancer vaccines may be an effective treatment strategy for early-stage cancers, but the treatment of advanced-stage cancers currently does not appear to be realistic.

(Source: Visual China)

The threshold is lowered, is BMI the only evaluation criterion for bariatric surgery?

Recently, the American Society for Metabolic Bariatric Surgery (ASMBS) and the International Federation of Obesity and Metabolic Surgery (IFSO) jointly issued a statement to comprehensively lower the threshold for bariatric surgery, and separately put forward the applicable indications for Asian populations, saying that BMI ≥ 25 indicates clinical obesity. , ≥27.5, bariatric surgery can be considered.

The relevant guidelines and consensuses in my country have also made a personalized definition based on the characteristics of “Chinese-style obesity”. The Expert Consensus on Obesity Prevention and Control among Chinese Residents (2022) pointed out that it is recommended to use BMI=24.0-27 and BMI≥28 to define overweight and obesity. Compared with China’s bariatric surgery guidelines, the latest announcements from ASMBS and IFSO may expand the population for surgery. The “Chinese Expert Consensus on Precision Obesity Metabolic Surgery (2022 Edition)” stated that relying solely on BMI classification cannot accurately reflect the complexity and heterogeneity of obesity. The aforementioned latest statement also pointed out that the BMI value alone cannot be used to delineate the suitable population for bariatric surgery.

(Source: Visual China)

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